Two sample MR report
HLA-DQA2_T Proliferating against finn-b-ASTHMA_ALLERG_EXMORE
Date: 13 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 44 | -0.0132556 | 0.0443742 | 0.7666253 |
| Weighted median | 44 | 0.0118644 | 0.0084783 | 0.1616951 |
| Inverse variance weighted | 44 | 0.0132017 | 0.0062447 | 0.0345094 |
| Simple mode | 44 | 0.0180073 | 0.0168390 | 0.2908652 |
| Weighted mode | 44 | 0.0176082 | 0.0169572 | 0.3048923 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 16.22557 | 42 | 0.9998865 |
| Inverse variance weighted | 16.58825 | 43 | 0.9999070 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| 0.0223456 | 0.0371051 | 0.5502627 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0.0006206 | 0 | TRUE | 0.017986 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
